A kan Nuwamba 9, 2021, bambance-bambancen nacutar coronavirus sabuwaAn gano B.1.1.529 a karon farko daga samfurin shari'ar Afirka ta Kudu.A cikin kasa da makonni 2, nau'in mutant ya zama babban nau'in nau'in maye gurbi na sabon kamuwa da kambin Afirka ta Kudu, kuma saurin karuwarsa ya jawo hankalin duniya.A ranar 26 ga Nuwamba, WHO ta ayyana wannan nau'in mutant a matsayin "bambancin damuwa" na biyar (VOC), mai suna Omicron (Omicron) mutant.A halin yanzu, nau'in nau'in Omicrom ya bazu cikin sauri zuwa kasashe ko yankuna 19 na duniya, kuma yana iya haifar da sabon zagaye na ƙalubale mai tsanani ga rigakafi da shawo kan cutar ta duniya.
WHO ta kuma bayyana cewa Omicron yana da adadi mai yawa na maye gurbi, wasu daga cikinsu suna da damuwa.Hukumar ta WHO ta kuma bayyana cewa ana iya gano nau'in mutant na "Omicron" da sauri fiye da sauran nau'ikan halittun da suka haifar da karuwar cututtuka a baya, wanda ke nuna cewa wannan sabon nau'in mutant na iya samun ci gaba.Tsananin hana yaduwar nau'in mutant na sabon coronavirus Omicron ya zama sabon manufa don rigakafin cutar ta duniya.
Taswirar rarraba maye gurbi na Omicron(1)da Delta(2), Jami'ar Stanford Coronavirus da Data Resistance Database
Baya ga samun ƙarin maye gurbi a cikin furotin mai karu, nau'in mutant na Omicron shima yana da wuraren maye gurbi a cikin furotin N.Tunda babban makasudin sabon coronavirus gano maganin antigen shine furotin N, maye gurbin furotin N na iya shafar sabon coronavirus antigen.Daidaitaccen kayan gwajin yana da tasiri.
| Tebur 1. Kwatanta juyin halittar N sunadaran halittu daban-daban
| |
| Karfin ƙwayar cuta
| N furotin juyin halitta |
| Alpha (B.1.1.7) | R203K;G204R; (> 50%) S194L (5-50%) D3H;D63G;T205I;M234I(1-5%) |
| Beta (B.1.351) | T205I (> 50%) P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| Gamma (shafi na 1) | P80R; S202C; R203K; G204R (> 50%) A211S; D402Y; S4131 (1-5%) |
| Delta (B.1.617.2) | D63G; R203M; G215C; D377Y (> 50%) Q9L (> 5-50%) G18V; R385K (1-5%)
|
| Omicron (B.1.1.529) | P13L;R203K;G204R E31/R32/S33 Del |
Idan aka kwatanta da furotin na Alpha-N, furotin Omicron-N yana da bambanci na matsayi 10 na amino acid.Domin bincika aikin gano furotin Omicron-N ta hanyar covid-19 antibody raw material na Keygen gene, mun shirya recombinant Omicron-N protein a karon farko , Kuma mun gudanar da tabbacin haɗin gwiwa ta Keygen Gene da adadin abokan ciniki.Sakamakon ya nuna cewa buɗaɗɗen ra'ayi sabon kambi na rigakafin jiki yana da sakamakon gano iri ɗaya don furotin Omicron-N mai sake haɗawa, furotin Alpha-N da furotin Delta-N.Buɗaɗɗen ra'ayi sabon kambi na rigakafin mutum na iya tabbatar da daidaiton sabon kayan antigen na kambi don gano bambance-bambancen Omicron..
| Table 2 Sakamako na gano furotin Omicron recombinant N ta neocorona antibody | ||||||
| Antibody Haɗe | Alpha-Nprotein | Omicron-Nprotein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Tsari 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Tsari 2 | G5 | G4 | G2 | G5 | G4 | G2 |
Katin nunin zinari na Colloidal
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Lokacin aikawa: Dec-14-2021
